abstract：:Paraquat is a broad spectrum herbicide known to be highly lethal to man and animals. Its toxicity is characterized by acute lung injury. Paraquat produces such toxic effects through the generation of the superoxide anion according to one proposed mechanism. The present experiment, methemoglobin formation was demonstra...

journal_title：Acta medica Okayama

authors： Watanabe S,Ogata M

更新日期：1982-12-01 00:00:00

abstract：:Differences in urinary excretion of monochlorobenzene between rats and humans were studied. Monochlorobenzene was administered to rats and humans intraperitoneally, orally or by inhalation. Urinary p-chlorophenylmercapturic acid and 4-chlorocatechol, after hydrolysis of its conjugate, were measured. The excretion of p...

journal_title：Acta medica Okayama

authors： Ogata M,Shimada Y

更新日期：1982-12-01 00:00:00

abstract：:Numerical changes in peripheral blood monocytes were examined in 125 patients with bronchial asthma using a new direct method of counting blood monocytes. The number of monocytes in non-attack stages of bronchial asthma was similar to that of healthy controls. The monocyte count observed in overall cases showed a sign...

journal_title：Acta medica Okayama

authors： Tanizaki Y,Hosokawa M,Goda Y,Akagi K,Takeyama H,Kimura I

更新日期：1982-10-01 00:00:00

abstract：:Under barbiturate anesthesia, male Wistar rats weighing 250-300 g were injected with 2.5 microliters of 0.2 M FeCl3 solution into the left sensori-motor cortex to induce an epileptic focus with minimal abnormal activities. Polygraphy started 1 week after the surgery, showed a spindle-like hypersynchronous activity tha...

journal_title：Acta medica Okayama

authors： Uezu E,Hori Y

更新日期：1982-06-01 00:00:00

abstract：:Volume-time (V-T) and flow-volume (F-V) curves were measured in all the subjects of nonsmoking young males (mean value 26.3 yrs.), healthy and asthmatic. Eleven parameters of pulmonary function tests, which were composed of two V-T, six F-V, and three mean time constants (MTC) parameters, were calculated from the curv...

journal_title：Acta medica Okayama

authors： Meguro T,Ogata M

更新日期：1982-04-01 00:00:00

abstract：:Nine eyeballs were enucleated from nine patients with excessive myopia, secondary retinochoroidal atrophy, absolute glaucoma, uveal malignant melanoma, Behçet's disease and sympathetic ophthalmia. The retina and choroid were studied with light and electron microscopes. The results were: In excessive myopia, marked blo...

journal_title：Acta medica Okayama

authors： Okabe S,Matsuo N,Okamoto S,Kataoka H

更新日期：1982-02-01 00:00:00

abstract：:The usefulness of liposomes (in neutral, positively and negatively charged forms) as a carrier for adriamycin (ADM) was studied by examining the distribution of ADM and related fluorescent compounds in Ehrlich solid tumor-bearing mice. The mice were given free or liposome-entrapped ADM intraperitoneally. The distribut...

journal_title：Acta medica Okayama

authors： Shinozawa S,Araki Y,Oda T

更新日期：1981-12-01 00:00:00

abstract：:Masugi nephritis was induced in rats by a single intravenous injection of rabbit anti-rat kidney serum, and studied with a scanning electron microscope. A characteristic finding was the presence of white cells, probably polymorphonuclear leukocytes, with many microspikes which penetrated through degenerated glomerular...

journal_title：Acta medica Okayama

authors： Makino H,Takaoka M,Komoda K,Tokuyama K,Ota Z,Ofuji T,Kaneshige T

更新日期：1981-11-01 00:00:00

abstract：:In order to get precise information about the movement of plasma membrane proteins in cap formation, cyto- and bio-chemical analyses were made of the plasma membranes from non-capped areas of Ehrlich ascites tumor cells (EATCs) exposed to concanavalin A (Con A). Blebs formed by treatment with cytochalasin B (CB) of th...

journal_title：Acta medica Okayama

authors： Nakamoto S

更新日期：1981-10-01 00:00:00

abstract：:Arginine vasopressin (AVP) was released in vitro in a pulsatile pattern from the hypothalamo-neurohypophyseal system (HNS) and from the hypothalamus during continuous hyperosmotic stimuli with NaCl or fructose. No significant difference was found in the AVP pulse frequency between the two kinds of hyperosmotic agents....

journal_title：Acta medica Okayama

authors： Ohno N

更新日期：1981-06-01 00:00:00

abstract：:A female patient who died of apparent postradiation sarcoma in the inguinal region after irradiating a metastatic squamous cell carcinoma of the same site was reported. For approximately 20 months, the patient had received a total of 6,600 and 9,600 Roentgen to the right para-aortic and inguinal areas, respectively. A...

journal_title：Acta medica Okayama

authors： Tanaka T,Murakami I,Awai S,Ogura Y,Morishita Y

更新日期：1981-04-01 00:00:00

abstract：:The levels of HDL-cholesterol and gamma-glutamyltransferase in the sera of 17 patients with alcoholic liver injury were followed after abstinence and compared with those of 11 patients with acute non-alcoholic hepatitis. The activity of gamma-glutamyltransferase decreased in all cases irrespective of the type of liver...

journal_title：Acta medica Okayama

authors： Ide T,Taketa K,Watanabe M,Ikeda S,Izumi M,Sokabe T,Kono H,Yamamoto Y

更新日期：1980-11-01 00:00:00

abstract：:A 73-year-old man with a left testicular tumor is presented. Orchiectomy was performed and the tumor was diagnosed as a plasmacytoma. There has been no bone lesion or immunoglobulin abnormality during a follow-up period more than one year. For several reasons, the tumor was regarded as a primary plasmacytoma of the te...

journal_title：Acta medica Okayama

authors： Kaneshige T,Asahi T,Matsumura Y,Ohmori H,Okamoto T,Tanaka T

更新日期：1980-11-01 00:00:00

abstract：:In 156 cases of gastric cancer, levamisole (LMS) was administered at a daily dose of 150 mg for three consecutive days every other week. The administration was started 3 days before operation. This medication was repeated for more than one month. The survival rate up to two years after surgery was studied. The surviva...

journal_title：Acta medica Okayama

authors： Miwa H,Ono F,Moriyama M,Kobayashi T,Oka T,Nakamura K,Orita K

更新日期：1980-09-01 00:00:00

abstract：:Immune complexes in liver specimens from 10 patients with chronic liver diseases [2 with chronic persistent hepatitis (CPH), 3 with chronic aggressive hepatitis (CAH) of moderate activity, 3 with CAH of severe activity, and 2 with liver cirrhosis] were examined by a technique of direct immunofluorescence using FITC-la...

journal_title：Acta medica Okayama

authors： Tsuji T,Araki K,Inoue J,Onoue K,Tsuchiya M,Shinohara T,Nagashima H,Nakashima A,Naito K,Arborgh B

更新日期：1980-06-01 00:00:00

abstract：:Fragmented sheep red blood cell (SRBC) membrane was used for detection of T-cells in liver biopsy specimens from patients with chronic active hepatitis. SRBC was separated with Lymphoprep, sonicated, then filtered through a 3 mu Millipore-membrane as a fragmented SRBC reagent. Tissue T-cells were stained by an indirec...

journal_title：Acta medica Okayama

authors： Tsuji T,Inoue J,Shinohara T,Tsuchiya M,Onoue K,Araki K,Nagashima H,Nakashima A,Naito K

更新日期：1980-02-01 00:00:00

abstract：:In the six cases of tumor-forming type as described in the part I of this series, the estimated ages at disease onset ranged from 55 to 82 years old. Tumor-forming sites consisted of three cases each in skull and ribs, and one each in pelvis and palate. Bone x-rays revealed usually larger punched-out lesions adjacent ...

journal_title：Acta medica Okayama

authors： Sezaki T,Hujita M,Oka A,Tanaka T

更新日期：1979-12-01 00:00:00

abstract：:Three patients at various stages of remission from leukemia died following the development of massive liver necrosis within only 4-6 days. All had either hepatitis B surface antigen or antibody in their sera, and two of them experienced severe epigastric pain before the onset of liver injury. Hepatitis B surface antig...

journal_title：Acta medica Okayama

authors： Watanabe A,Higashi T,Endo H,Nagashima H

更新日期：1979-08-01 00:00:00

abstract：:The alterations of lipid composition in sera of patients with liver diseases, particularly intrahepatic cholestasis and biliary obstruction, were studied by ultracentrifugation and polyacrylamide-gel disc-electrophoresis of lipoproteins and apoproteins. The elevation of serum cholesterol in intrahepatic cholestasis wa...

journal_title：Acta medica Okayama

authors： Watanabe M

更新日期：1979-08-01 00:00:00

abstract：:The level of blood catalase activity in heterozygotes for Japanese type acatalasemia was demonstrated to be about half of normal levels by means of titration and spectrophotometric methods. A distribution plot of catalase activities in heterozygous blood was completely separate from that of normal blood. Comparative a...

journal_title：Acta medica Okayama

authors： Ogata M,Mizugaki J

更新日期：1979-06-01 00:00:00

abstract：:Human cells derived from malignant tumors (HeLa, HEp-2 and KB) and human cells transformed by tumor viruses (KCand RSb) formed syncytia by simian sarcoma virus type I (SSV-I/SSAV-I), but human diploid or non-transformed cells (WI-38, HEL and HEC) did not. ...

journal_title：Acta medica Okayama

authors： Ocho M,Ogura H,Tanaka T,Oda T

更新日期：1979-04-01 00:00:00

abstract：:A study of 52 liver biopsies (47 hepatitis type B and 5 asymptomatic carriers) was performed to clarify the roles of HBe antigen (HBeAg), HB surface antigen (HBsAg) and HB core antigen (HBcAg). In this study, the Gudat classification was modified so as to classify the patterns of HB antigens into six reaction types in...

journal_title：Acta medica Okayama

authors： Tsuji T,Naito K,Inoue J,Tsuchiya M,Araki K,Shinohara T,Onoue K,Nagashima H,Tokuyama K,Okada T

更新日期：1979-04-01 00:00:00

abstract：:Levamisole was administered to 177 patients with gastrointestinal cancer (88 curative resection, 58 noncurative resection and 31 without resection). It was administered at a daily dose of 150 mg for three consecutive days every other week. The administration was started, as a rule, 3 days before operation. This medica...

journal_title：Acta medica Okayama

authors： Miwa H,Orita K

更新日期：1979-02-01 00:00:00

abstract：:The homovanillic acid (HVA) concentrations in the lumbar cerebrospinal fluid (CSF) were determined in 38 epileptic and 39 control patients. The mean concentration of HVA was 23.9 ng/ml +/- 2.8 SEM for the epileptic group and 30.2 ng/ml +/- 2.1 SEM for the control group, respectively. Thus, HVA was significandly reduce...

journal_title：Acta medica Okayama

authors： Kobayashi K,Koide Y,Doi T,Kohsaka M,Hosokawa K,Oku Y

更新日期：1978-08-01 00:00:00

abstract：:A new instrument for visual field examination with binocular fixation is described. The binocular vision was dissociated with polarizing plates. Only the point of fixation was visible to both eyes while the testing chart (Amsler chart) was visible to one eye in the use of this apparatus. The examination was done with ...

journal_title：Acta medica Okayama

authors： Hasegawa E

更新日期：1978-07-01 00:00:00

abstract：:Endotoxin (lipopolysaccharide, LPS) and LPS antibody in the blood were studied in 61 cases of ulcerative colitis (U.C.) by radioimmunoassay. Lysozyme (LZM) concentration was also studied by the turbidimetric method. As a result, it was found that the blood LPS value as well as serum LZM concentration reflects the clin...

journal_title：Acta medica Okayama

authors： Aoki K

更新日期：1978-06-01 00:00:00

abstract：:The effect of various hormones on cytological and biochemical properties of cultured hepatic cells were investigated in order to obtain long-term survival of the hepatocytes with adult liver functions in primary culture. Insulin supplementation of the culture medium enhanced the attachemnt efficiency of cells in prima...

journal_title：Acta medica Okayama

authors： Miyazaki M,Watanabe A,Shiraishi M,Hoshika T,Miyano K,Sato J

更新日期：1978-06-01 00:00:00

abstract：:Reconstituted complexes of DNA with histone were prepared by salt-and-urea step gradient dialysis. The DNA was complexed with histone H1, with the combination of the other four histones H2A, H2B, H3 and H4, and with whole histones. These DNA-histone complexes were purified by Bio-Gel column chromatography, and the wei...

journal_title：Acta medica Okayama

authors： Oda T,Omura S,Hidaka H

更新日期：1977-10-01 00:00:00

abstract：:Human KC cell monolayer inoculated with concentraten Mason-Pfizer monkey virus (MPMV) showed syncytia formation within an hour. The cell fusion was blocked by the treatment of the MPMV with neutralizing antiserum. Treatment of the MPVM with beta-propiolactone resulted in the loss of infectivity although KC cell fusion...

journal_title：Acta medica Okayama

authors： Ogura H,Oda T

更新日期：1977-08-01 00:00:00

abstract：:The relationship between immune insulitis and glucose tolerance was investigated in three groups of mice following active immunization with different components of bovine pancreatic hormone. An abnormal blood glucose level was observed in the three groups ranging from 33.3% to 87.5% of sensitized mice. A relationship ...

journal_title：Acta medica Okayama

authors： Okada S,Yagyu F,Kawanishi K,Ofuji T

更新日期：1977-06-01 00:00:00

abstract：:Deoxyuridine suppression tests have been performed by two different methods of six normoblastic and eight megaloblastic marrows. A good correlation was obtained between the results by the modified and the original methods. The simplified method was found to be applicable for a clinical purpose to diagnose megaloblasto...

journal_title：Acta medica Okayama

authors： Taguchi H,Stafford DM,Chanarin I

更新日期：1977-04-01 00:00:00

abstract：:The effect of an intravenous injection of squid-ink (sepia-melanin) solution on adult mouse spheroid alveolar epithelial cells was observed by the electron microscope. Sepia-melanin particles were seen in all alveolar wall cells examined that seems to suggest the entrance of sepia-melanin particles into the spheroid a...

journal_title：Acta medica Okayama

authors： Suwa K

更新日期：1977-02-01 00:00:00

abstract：:Forty-five patients with acute leukemia were compared on cellular immunity measures versus prognosis. The patients were treated according a multicombination therapy protocol. The purified protein derivative (PPD) test and dinitrochlorobenzene (DNCB) test on admission indicated low positive percentages. In acute non-ly...

journal_title：Acta medica Okayama

authors： Toki H,Takahashi Y,Nakanishi N,Naito T,Chen P,Takahashi I,Kitajima K

更新日期：1977-02-01 00:00:00

abstract：:It is the purpose of this paper to alert the medical community on the potential nephrotoxicity of certain agents among certain patients, especially with some types of renal insufficiency. A young man, who was suffering from apparent renal disturbance, died of massive, post-operative bleeding accompanied by uremia. The...

journal_title：Acta medica Okayama

authors： Tanaka T,Kitajima K,Naito T,Hurutani S,Ogura S

更新日期：1976-10-01 00:00:00

abstract：:In order to formulate an early diagnostic method for acute rejection after kidney transplantation, macrophage migration inhibition test (MIT) was carried out with lapse of time after inbred rat kidney allotransplantation. The mean survival time of rat kidney allograft was found to be 7.07 +/- 1.34 days. On the other h...

journal_title：Acta medica Okayama

authors： Sakagami K

更新日期：1976-06-01 00:00:00

abstract：:The root and stem decoctions of Sinomenium acutum Rehd. et Wils. (formerly Sinomenium diversifolius Diels, one type of Fang-chi (Chinese)) have been used as a folk remedy for neuralgia and rheumatoid arthritis in many areas of the Far East. In Japan and China various viny plants have been identified as Fang-chi (Boi i...

journal_title：Acta medica Okayama

authors： Yamasaki H

更新日期：1976-02-01 00:00:00

abstract：:Hepatitis B core antigen (HBc Ag) and hepatitis B surface antigen (HBs Ag) were detected in the liver tissue of a patient with chronic aggressive hepatitis by the immunofluorescent complement technique. The presence of anti-HBc was examined by the same method in 67 human sera previously tested for HBs Ag, anti-HBs and...

journal_title：Acta medica Okayama

authors： Tsuji T,Tokuyama K,Okada T,Takata S,Naito K

更新日期：1976-02-01 00:00:00

abstract：:The presence of specific serum antibodies in five myasthenia gravis patients was demonstrated against the motor endplates and muscle membranes of rats by membrane immunofluorescence technique. The immunologic specificity of the antibodies was confirmed. The clinical significance is discussed. ...

journal_title：Acta medica Okayama

authors： Arimori S,Tada S,Nakata Y,Kobashi H,Ichikawa Y

更新日期：1975-12-01 00:00:00

abstract：:Cholesterol, cholesteryl esters, triglycerides and fatty acids as major neutral lipids and phospholipids were examined in quantitative analysis. The method consisted of three steps: (1) separation of lipids by one-dimensional thin-layer chromatography on silica gel plates; (2) elution of neutral lipids from scraped si...

journal_title：Acta medica Okayama

authors： Okabe A

更新日期：1975-08-01 00:00:00

abstract：:A study was carried out to clarify the mechanism of nuclear extrusion of mammalian erythroid cells by observing erythroblasts of rabbit under various conditions in vitro. The animals were made anemic by phenylhydrazine injection and erythroblasts were obtained from the peripheral blood and observed morphologically aft...

journal_title：Acta medica Okayama

authors： Mori M

更新日期：1975-06-01 00:00:00